CD99-Positive “Ewing's Sarcoma” from Mouse Bone Marrow–Derived Mesenchymal Progenitor Cells?
نویسندگان
چکیده
منابع مشابه
CD99-positive "Ewing's sarcoma" from mouse-bone marrow-derived mesenchymal progenitor cells?
One of the unsolved enigmas of Ewing’s sarcoma family of tumors (ESFT) is its histogenetic origin. Lately, evidence has been accumulating that boneor bone marrow–derived mesenchymal progenitor cells (MPC) can be transformed by EWS-FLI1 causing small-round cell-like tumors in mice. This observation was extended recently in a report by Riggi et al. (1). Riggi et al. (1) report that EWS-FLI1 is ca...
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Ewing's sarcoma is a member of Ewing's family tumors (EFTs) and the second most common solid bone and soft tissue malignancy of children and young adults. It is associated in 85% of cases with the t(11;22)(q24:q12) chromosomal translocation that generates fusion of the 5' segment of the EWS gene with the 3' segment of the ETS family gene FLI-1. The EWS-FLI-1 fusion protein behaves as an aberran...
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Rabbits have the capacity to regenerate holes in their ears by forming a blastema, a tissue that is made up of a group of undifferentiated cells. The purpose of the present study was to isolate and characterize blastema progenitor cells and compare them with marrow mesenchymal stem cells (MSCs). Five New Zealand white male rabbits were used in the present study. A 2-mm hole was created in the a...
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In the bone marrow, there are certain populations of stem cell sources with the capacity to differentiate into several different types of cells. Ideally, cell transplants would be readily obtainable, easy to expand and bank, and capable of surviving for sufficient periods of time. Bone marrow mesenchymal stem cells (BM-MSCs) possess all of these characteristics. One of the most important benefi...
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ژورنال
عنوان ژورنال: Cancer Research
سال: 2006
ISSN: 0008-5472,1538-7445
DOI: 10.1158/0008-5472.can-06-0205